Download Adaptive Dynamics of Infectious Diseases: In Pursuit of by Ulf Dieckmann, Johan A. J. Metz, Maurice W. Sabelis, Karl PDF

By Ulf Dieckmann, Johan A. J. Metz, Maurice W. Sabelis, Karl Sigmund

This monograph takes inventory of our present wisdom at the evolutionary ecology of infectious ailments, and units out the ambitions for the administration of virulent pathogens. during the textual content, the basic suggestions and methods underlying the versions are conscientiously defined in a distinct sequence of built-in containers.

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Additional info for Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management

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Therefore, to eradicate a disease through vaccination an effective vaccination coverage of p > 1 − 1/R0 is required. In models that exclude within-host interactions between disease strains (as results from multiple infections or when recovery does not result in full immunity), R0 can serve as a convenient yardstick to assess the evolutionary dynamics of a disease: strains with a higher R0 outcompete strains with a lower R 0 . This implies that the introduction and fixation of mutational variation increases the R 0 value of a disease until the evolutionary options for further increase are exhausted.

5). This analysis therefore illustrates how the presence of opportunities for waterborne transmission may affect the outcome of virulence evolution, even though models that consider overall levels of hygiene (rather than differential effects of hygiene on different modes of transmission) do not show analogous effects. If the rate ρ of propagule release per host is considered to be an increasing saturating function of α (in accordance with assumptions made by Bonhoeffer et al. 1996), the overall results are similar.

1 continued The same applies to B, with Bproportions = Bdensities /N0 = d; all the other coefficients do not change in meaning. To achieve a better match between models and reality it may sometimes be necessary to subdivide the classes of susceptible and infective hosts on the basis of inherent differences between host individuals (such as differences in age). 3). 1 Categories of transmission modes that have been studied using SIR or SI models. Transmission mode Description Dependent on host mobility?

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